Introduction: Solitary adenoma is the cause of primary hyperparathyroidism in 85% of cases.
Objectives: In this study, we aimed to evaluate the routine necessity of frozen section (FS) in patients with well-localized solitary parathyroid adenoma in the absence of intraoperative parathyroid hormone (IOPTH) measurement and gamma probe usage.
Patients and Methods: Fourty-four patients had tissue samples submitted for intraoperative FS consultation. Two surgeons’ opinion on the excised tissue were recorded independently and compared with the histopathology reports.
Results: In the postoperative 24 hour blood calcium and PTH levels in patients with SPA were found to be significantly lower when compared with preoperative levels (P = 0.001). All patients had samples sent for intra-operative FS where 100% of samples were found to be parathyroid tissue.
Conclusion: Parathyroid adenoma excision can be safely and successfully performed without the need for FS examination in patients with well localized solitary adenomas. Although our study is encouraging, further studies are still needed on this subject.