Nickan Research Institute Journal of Parathyroid Disease 2345-6558 13 1 2025 01 01 Quality of life among primary hyperparathyroidism patients with recurrent renal stone disease: A comparative analysis of surgical and non-surgical management groups e12279 e12279 10.34172/jpd.2025.12279 EN Malik Ayyad https://orcid.org/0000-0002-8962-3591 Omar Ayaad https://orcid.org/0000-0003-1521-117X Hassan Alkhatatbeh Bayan Qaddumi Fadi Sawaqed https://orcid.org/0000-0002-5743-880X Samer Al-Rawashdeh Journal Article 10.34172/jpd.2025.12279 2024 11 27 2025 04 06 Introduction: Renal stone disease (nephrolithiasis) is a common condition linked to significant morbidity, with primary hyperparathyroidism (PHPT) identified as a key contributor in recurrent cases. While parathyroidectomy remains the gold-standard treatment, the comparative impact of surgical and non-surgical approaches on quality of life (QoL) remains inadequately explored. Objectives: To evaluate the impact of parathyroidectomy on QoL and compare the effectiveness of surgical and non-surgical management in enhancing physical, emotional, and social well-being among patients with PHPT and recurrent renal stone disease. Patients and Methods: This cross-sectional study included 84 participants diagnosed with PHPT and recurrent renal stones, recruited from private hospitals in Jordan. Participants were divided into two groups: post-parathyroidectomy (n=46) and non-surgical (n=38). Quality of life was assessed using the short form health survey (SF-36), focusing on eight health domains. Data were collected online and analyzed using SPSS (version 27). Independent T-test was conducted to compare QoL outcomes between the groups, with statistical significance set at p < 0.05. Results: Post-parathyroidectomy patients reported significantly higher QoL scores in physical functioning (mean: 4.80 versus 3.45, P<0.05), bodily pain (4.89 versus 3.32, P<0.05), and general health perceptions (4.70 versus 3.26, P<0.05). The total QoL score was significantly greater in the surgical group (mean: 36.91 versus 27.08, P<0.05). However, no significant differences were observed in social functioning, mental health, or role-emotional functioning between the two groups. Conclusion: Parathyroidectomy significantly improves physical functioning, pain reduction, and overall health perceptions in patients with PHPT and recurrent renal stones. However, emotional and social domains remain similar to non-surgical management, indicating the need for integrated psychosocial support alongside physiological interventions to optimize QoL.