Nickan Research Institute Journal of Parathyroid Disease 2345-6558 11 1 2023 01 01 Cinacalcet in patients with primary hyperparathyroidism; a review e11226 e11226 10.34172/jpd.2023.11226 EN Hamid Reza Hemmati https://orcid.org/0000-0002-9512-3120 Journal Article 10.34172/jpd.2023.11226 2023 05 26 2023 08 13 Primary hyperparathyroidism (PHPT) is a condition characterized by the parathyroid glands’ overproduction of parathyroid hormone (PTH). These increases calcium levels in the blood, leading to various symptoms and complications. Cinacalcet is a promising therapeutic option for patients with PHPT who are unable or unwilling to undergo surgery. It effectively reduces serum calcium and PTH levels, improving biochemical markers of bone turnover and renal function. However, more research is needed to determine the optimal dosage, duration, and long-term effects of cinacalcet treatment in this patient population. Clinicians should carefully consider the risks and benefits of cinacalcet therapy individually and involve patients in shared decision-making.