Nickan Research Institute Journal of Parathyroid Disease 2345-6558 10 1 2022 01 01 Correlation of thyroid status with severity and mortality of COVID-19 patients e11161 e11161 10.34172/jpd.2022.11161 EN Elahe Zaremoghadam https://orcid.org/0000-0002-0550-0122 Ensiye Pordel https://orcid.org/0000-0002-1838-8707 Mostafa Assarroudi https://orcid.org/0000-0003-4718-6642 Saeid Mohammadi https://orcid.org/0000-0003-0844-8937 Ali Kalali Sani https://orcid.org/0000-0003-4972-9524 Hossein Mardanparvar https://orcid.org/0000-0001-7455-5373 Sara Abbasian https://orcid.org/0000-0003-3660-6672 Journal Article 10.34172/jpd.2022.11161 2021 08 19 2022 10 13 Introduction: Thyroid status because of the expression of angiotensin-converting enzyme-2 (ACE2), which is a functional receptor for coronavirus disease 2019 (COVID-19) in thyroid glands, maybe affects COVID-19 patients’ outcomes. Objectives: This study aimed to evaluate the correlation of thyroid status with the severity and mortality of COVID-19 patients. Patients and Methods: In a retrospective cohort study conducted on 521 COVID-19 patients, data were collected by a demographic questionnaire and a checklist of patient outcomes (death/recovery) from the hospital information system (HIS) and analyzed by SPSS version 26 and binary logistic regression. Data about thyroid status were collected from clinical documents and laboratory test data. Results: Most patients were male (57.2%) with a mean age of 56.12 ± 17.4 years. Seventy-seven patients had a severe stage of disease, and 55 patients died. Twenty-one patients had hyperthyroidism, and 53 patients had hypothyroidism. Results showed that the correlation between hypothyroidism and hyperthyroidism with severity and mortality risk of COVID-19 patients was insignificant (P > 0.05). Conclusion: In this study, we concluded that, thyroid status is not associated with COVID-19 outcomes such as severity or mortality.