Nickan Research Institute Journal of Parathyroid Disease 2345-6558 5 1 2017 01 01 Antioxidant efficacy of vitamin D 11 16 EN Zeinab Mokhtari Azita Hekmatdoost Mojgan Nourian Journal Article Vitamin D (vit D) is not only contributed to maintaining normal calcium metabolism, but also is crucial for an extensive range of non-classic actions. The antioxidant effect of vit D is between the newest suggested non-calcemic roles of this compound. According to the vit D deficiency could be related to several chronic diseases such as diabetes, cardiovascular disease and chronic kidney disease (CKD), it is proposed that vit D could involve in the development or progression of chronic diseases by modulating oxidative stress. In this review, we summarize the current evidence indicating the association between chronic diseases and oxidative stress considering the role of vit D on this relationship.