Nickan Research Institute Journal of Parathyroid Disease 2345-6558 4 2 2016 04 01 Antioxidants as a novel way to alleviate the adverse effects of oxidative stress in osteoporosis 60 65 EN Elaheh Jahanian Mansoor Karimifar Mahmoud Rafieian-Kopaei Journal Article Bone is a dynamic organ undergoing remodeling through the coordinated resorption and formation activities between osteoblasts and osteoclasts. Osteoporosis is regarded as degenerative disease that is one of the biggest problems in elderly people. Osteoporosis is a multi-factorial disease. Age-related oxidative stress causes osteoporosis via adversely affecting both osteoblasts and osteoclasts. On the other hands, one of defense mechanisms against reactive oxygen species is antioxidant. Fruits and vegetables are the sources of antioxidants alleviating osteoporosis caused by oxidative stress. Hence, the aim of this review article is to illustrate the favored effects of antioxidants therapy to mitigate osteoporosis caused by oxidative stress.