Nickan Research Institute Journal of Parathyroid Disease 2345-6558 4 2 2016 04 01 Ameliorative impact of vitamin D on hypertension 54 56 EN Sara Beigrezaei Hamid Nasri Journal Article Hypertension is a chronic disorder with serious risk factors for clinically important events including myocardial infarction, heartfailure, stroke and death. It is estimated that, 1.56 billion adults will be living with high blood pressure in 2025 and one in three adultshas hypertension in world. Vitamin D is a micronutrient with important implications for human health and has recognized functionsin calcium and bone metabolism. Low 25-hydroxyvitamin D levels are related to higher prevalence of blood pressure and evidencesfrom meta-analysis of cohort studies showed that vitamin D deficiency, predicts enhanced risk of all-cause mortality, cardiovasculardisease, and hypertension. Several mechanisms proposed that vitamin D decreases blood pressure. However, more studies arenecessary to find the influence of vitamin D on blood pressure in normal individuals and patients with chronic hypertension.