Perspectives on the relationship of urolithiatic markers and primary hyperparathyroidism

Abstract

Abnormal parathyroid hormone (PTH) secretion by parathyroid glands leads to hypoparathyroidism or hyperparathyroidism. Most of the hyperparathyroidism cases are asymptomatic and occult urolithiasis is present in about one-fifth of these patients. The marker associated with hyperparathyroidism and urolithiasis may aid in early diagnosis and prophylactic management of these conditions. The aim of the present review is to list the most widely measured markers in urolithiasis. The literature related to urolithiasis and hyperparathyroidism was collected from PubMed and Google Scholar. Serum, urine and genetic markers that were found associated with both urolithiasis hyperparathyroidism were discudded. Further studies on these markers may provide scope for early risk identification and management of the hyperparathyroidism.

Keywords: Parathyroid hormone, hyperparathyroidism, urolithiasis, hypercalcemia, serum creatinine