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J parathyr dis. 2016;4(2): 66-68.
  Abstract View: 1486
  PDF Download: 733

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Hypercalcemia and hyperparathyroidism in long-term lithium administration
 

Mahrang Hedaiaty 1, Mahsa Hedaiaty 2*

1 Clinical Toxicology Department, Isfahan Clinical Toxicology Research Center, Noor Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Radiology Department, Imam Khomeini Hospital, Lorestan University of Medical Sciences, Broujerd, Iran.
*Corresponding Author: *Corresponding author: Mahsa Hedaiaty,, Email: h_mahsa808@yahoo.com

Abstract

Lithium compounds are commonly used in the treatment and prophylaxis of mood disorders, multiple sclerosis, stroke insults, neurotoxicity associated to human immunodeficiency virus and Huntington disease. Although the clinical benefit of lithium salt has known over the long term, it is related to the risk of development of numerous adverse effects such as hyperparathyroidism and hypercalcemia. The exact pathogenic mechanism for abnormality or impairment in parathyroid during lithium therapy is however unknown. Lithium-associated hyperparathyroidism is often asymptomatic. The manifestations are resulted of the detrimental effects of chronic excessive secretion of parathyroid hormone following hypercalcemia to human body tissues. The calcium, parathyroid hormone and 1,25-hydroxycholecalciferol concentrations in blood should be monitored periodically during lithium treatment. Sometimes the cessation of lithium administration does not lead to normocalcemia, thus parathyroidectomy may indicate. Psychiatrists should be noted in screening for hyperparathyroidism and hypercalcemia in their older patients taking lithium, both prior to starting administration and at least annually thereafter.
 

Implication for health policy/practice/research/medical education
Lithium-associated hyperparathyroidism is often
asymptomatic. The manifestations are resulted of the
detrimental effects of chronic excessive secretion of
parathyroid hormone following hypercalcemia to human
body tissues. The calcium, parathyroid hormone and
1,25-hydroxycholecalciferol concentrations in blood should
be monitored periodically during lithium treatment.
Sometimes the cessation of lithium administration does
not lead to normocalcemia, thus parathyroidectomy may
indicate. Psychiatrists should be noted in screening for
hyperparathyroidism and hypercalcemia in their older
patients taking lithium, both prior to starting administration
and at least annually thereafter.

Please cite this paper as: Hedaiaty M, Hedaiaty M. Hypercalcemia and hyperparathyroidism in long-term lithium administration. J Parathyr Dis. 2016;4(2):66-68.

 
 
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ePublished: 05 Jun 2016
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