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J parathyr dis. 2016;4(2): 43-47.
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Secondary hyperparathyroidism in chronic hemodialysis patients in Khuzestan province, Iran
 

Fatemeh Hayati 1, Seyed Seifollah Beladi Mousavi 1*, Mohammad Faramarzi 1

1 Chronic Renal Failure Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran.
*Corresponding Author: *Corresponding author: Seyed Seifollah Beladi Mousavi, , Email: Beladimusavi@yahoo.com

Abstract

Introduction: Secondary hyperparathyroidism (SHPT) describes a complex alteration in bone and mineral metabolism which caused by several changes that occurs as a direct result of decreased kidney function

Objectives: The aim of this study is to determine the prevalence of SHPT and its relationship in end-stage renal disease (ESRD) patients living in the province of Khuzestan, Iran.

Patients and Methods: This cross-sectional study was conducted on hemodialysis patients in . Blood samples were obtained to check of intact parathyroid hormone (iPTH) level and routine laboratory studies including serum calcium, phosphorus, and alkaline phosphatase.

Results: One hundred twelve hemodialysis (HD) patients (49 females [43.7%] and 63 males [56.3%]) with mean age of 52.6±15.3 years were enrolled in the study. Seventy-eight patients had intact PTH above 300 ρg/mL, 22 patients had intact PTH between 150-300 ρg/mL and 12 patients had intact PTH below 50 ρg/mL. There was no significant difference in prevalence of SHPT between diabetic and nondiabetic HD. All of our patients had hyperphosphatemia.

Conclusion: According to the results of the study, a very significant percent of our HD patients have SHPT and the serum phosphorus level of these patients are outside the ranges suggested by K/DOQI guidelines. Hence, according to the consequences of SHPTH on progress of atherosclerosis and vascular calcification and therefore high rate of myocardial ischemia and heart failure among HD patients, more attention to this aspect of HD patients is necessary.

 

Implication for health policy/practice/research/ medical education

Chronic kidney disease-mineral and bone disorder is an important issue because disorders of mineral metabolism including hypercalcemia and hyperphosphatemia are thought to contribute to atherosclerosis and vascular calcification and therefore contribute to high rate of myocardial ischemia and heart failure among end-stage renal disease (ESRD) patients.

Please cite this paper as: Hayati F, Beladi Mousavi SS, Faramarzi M. Secondary hyperparathyroidism in chronic hemodialysis patients in Khuzestan province, Iran. J Parathyr Dis. 2016;4(2):43-47.

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ePublished: 06 May 2016
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