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Journal of Parathyroid Disease 2018;6(2):50-56 doi: 10.15171/jpd.2018.18
Bone mineral density and bone metabolism biochemical markers in patients with chronic kidney disease at the hemodialysis treatment

Original

Mohammad Reza Tamadon, Jamileh Moghimi * , Vahid Semnani

1 Department of Internal Medicine, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran


*Corresponding author: Jamileh Moghimi,
Email: moghimi_jam@yahoo.com


Abstract
Introduction: Chronic kidney disease (CKD) is associated with bone and mineral metabolism disorders.Objectives: This investigation studied the bone mineral density (BMD) and bone metabolism biochemical markers in patients with CKD at the hemodialysis treatment among a group of Iranian hemodialysis patients. We also sought to test the possible association of risk factors and biochemical parameters with BMD.Patients and Methods: In this cross sectional study, 77 patients with CKD stage 5D at the hemodialysis treatment. BMD was measured by dual-energy X-ray absorptiometry (DXA) at the anteroposterior lumbar spine (LS) (L1-L4) and left proximal femur. Biochemical markers, including calcium (Ca), phosphorus (P), intact parathyroid hormone (iPTH), serum specific alkaline phosphatase (ALP) and 25-hydroxy-vitamin D (25(OH)D) were measured to assess BMD loss.Results: Around two (2.6%) patients had normal levels of 25(OH) D (mean levels 17.67 ± 11.66 nmol/l). We found a reduction of BMD in comparison with age and gender-matched normal population values at the femoral neck (FN) (T-score = -1.92 ± 1.29), at the total hip (TH) (T-score = -1.79 ± 1.25) and at the lumbar spine (LS) (T-score = -1.55 ± 1.84). The prevalence of T-scores ≤ -2.5 SD was 28.6%, 35.1% and 13.0% according to LS, FN and three bone sites T scores respectively. BMD negatively correlated: with age at the proximal femur, with serum ALP at the lumbar spine and with age of menopause at the femoral neck.Conclusion: Patients with end-stage renal disease at the hemodialysis treatment had a high prevalence of osteoporosis in the general population. Bone mineral density at the all bone sites was below the expected average for gender and age.

Notes
Please cite this paper as: Tamadon MR, Moghimi J, Semnani V. Metabolic bone disease in end-stage renal disease patients under regular hemodialysis J Parathyr Dis. 2018;6(x):x-x. DOI: 10.15171/jpd.2018.x.Copyright © 2018 The Author(s); Published by Nickan Research Institute. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Creative Commons Attribution 4.0 License This work is licensed under a Creative Commons Attribution 4.0 License.
Copyright © 2016 The Author(s)
Published by Nickan Research Institute