Mohammad-Reza Ardalan
1, Houshang Sanadgol
2, Hamid Nasri
3, Azar Baradaran
4, Mohammad-Reza Tamadon
5, Mahmoud Rafieian-Kopaei
6*1 Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Nephrology, Zahedan University of Medical Sciences, Zahedan, Iran.
3 Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.
4 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
5 Department of Nephrology, Semnan University of Medical Sciences, Semnan, Iran.
6 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Abstract
When chronic kidney disease progresses, the capability to compensate for elevation in parathyroid hormone and fibroblast growth factor-23 and for decrease in 1,25(OH)2D3 become insufficient, which consequences in high serum phosphorus level, extra-skeletal calcification and abnormal bone disorders. Further to its effect on the regulation of parathyroid hormone, calcium and phosphate, vitamin D has various other non-calciotropic efficacies, comprising controlling cell proliferation/differentiation and having immunomodulatory properties. There are various immune disturbances that can be observed when function deteriorates. It is necessary to understand well both the classical and non-classical functions of vitamin D.
Implication for health policy/practice/research/ medical education
When chronic kidney disease progresses, the capability to compensate for elevation in parathyroid hormone and fibroblast growth factor-23 and for decrease in 1,25(OH)2D3 become insufficient, which consequences in high serum phosphorus level, extra-skeletal calcification and abnormal bone disorders. Further to its effect on the regulation of parathyroid hormone, calcium and phosphate, vitamin D has various other non-calciotropic efficacies, comprising controlling cell proliferation/differentiation and having immunomodulatory properties. There are various immune disturbances that can be observed when function deteriorates. It is necessary to understand well both the classical and non-classical functions of vitamin D.
Please cite this paper as: Ardalan MR, Sanadgol H, Nasri H, Baradaran A, Tamadon MR, Rafieian-Kopaei R. Impact of vitamin D on the immune system in kidney disease. J Parathyr Dis 2013; 1(2): 17-20.